Title : Rotundarpene inhibits toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways.

Pub. Date : 2014 Feb

PMID : 24378401






1 Functional Relationships(s)
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1 Rotundarpene, Akt inhibitor, Bay 11-7085 and N-acetylcysteine each attenuated the lipoteichoic acid- or peptidoglycan-induced production of cytokines and chemokines, expression of TLR-2, activation of NF-kappaB and Akt, and formation of reactive oxygen species in keratinocytes. Acetylcysteine AKT serine/threonine kinase 1 Homo sapiens