Title : Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells.

Pub. Date : 2015 Feb 1

PMID : 25444914






2 Functional Relationships(s)
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1 Pretreatment of cells with the ROS scavenger N-acetylcysteine completely blocked the apoptosis induced by combination treatment, and recovered expression of AKT inactivation, which revealed the important role of ROS in apoptosis and AKT regulation. Acetylcysteine AKT serine/threonine kinase 1 Homo sapiens
2 Pretreatment of cells with the ROS scavenger N-acetylcysteine completely blocked the apoptosis induced by combination treatment, and recovered expression of AKT inactivation, which revealed the important role of ROS in apoptosis and AKT regulation. Acetylcysteine AKT serine/threonine kinase 1 Homo sapiens