Melatonin

AKT serine/threonine kinase 1 ; Homo sapiens







98 Article(s)
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1 34725795 Effect of Apatinib plus melatonin on vasculogenic mimicry formation by cancer stem cells from breast cancer cell line. 2022 Mar 3
2 34953312 Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome. 2022 Mar 3
3 35607451 Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway. 2022 6
4 35625825 Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells. 2022 May 7 2
5 33016468 Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6. 2021 Jan 1
6 33226571 Melatonin upregulates DNA-PKcs to suppress apoptosis of human umbilical vein endothelial cells via inhibiting miR-101 under H2O2-induced oxidative stress. 2021 Feb 6
7 34079331 Melatonin Inhibits Migration and Invasion in LPS-Stimulated and -Unstimulated Prostate Cancer Cells Through Blocking Multiple EMT-Relative Pathways. 2021 1
8 34165162 Treatment with melatonin ameliorates febrile convulsion via modulating the MEG3/miR‑223/PTEN/AKT signaling pathway. 2021 Aug 1
9 34396568 Melatonin and its derivative disrupt cancer stem-like phenotypes of lung cancer cells via AKT downregulation. 2021 Dec 1
10 34580235 Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells. 2021 Sep 27 4
11 34660789 Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture. 2021 3
12 34758863 Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS. 2021 Nov 11 1
13 31605630 Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy. 2020 Jan 1
14 32052470 Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides. 2020 Apr 4
15 32096202 Melatonin reduces OGD/R-induced neuron injury by regulating redox/inflammation/apoptosis signaling. 2020 Feb 2
16 32179814 Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process. 2020 Mar 16 2
17 32547319 Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis. 2020 1
18 32598308 Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells. 2020 Jun 29 2
19 32600435 Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway. 2020 Jun 29 1
20 32649783 Melatonin improves cryopreservation of ram sperm by inhibiting mitochondrial permeability transition pore opening. 2020 Sep 1
21 32758663 Melatonin inhibits the apoptosis of rooster Leydig cells by suppressing oxidative stress via AKT-Nrf2 pathway activation. 2020 Nov 20 5
22 32791190 Melatonin stimulates VEGF expression in human granulosa-lutein cells: A potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome. 2020 Dec 1 1
23 32792862 Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling. 2020 3
24 32811805 Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis. 2020 Aug 18 1
25 32863233 Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway. 2020 Sep 2
26 32901009 Correction: Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis. 2020 Sep 8 1
27 32935463 Melatonin synergizes BRAF-targeting agent dabrafenib for the treatment of anaplastic thyroid cancer by inhibiting AKT/hTERT signalling. 2020 Oct 2
28 32962330 Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke 2020 Nov 3 1
29 33065391 Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway. 2020 Dec 1
30 33571963 Nanomolar melatonin influences insulin synthesis and secretion in rat insulinoma INS-1E cells. 2020 Oct 2
31 30372570 Melatonin-mediated downregulation of ZNF746 suppresses bladder tumorigenesis mainly through inhibiting the AKT-MMP-9 signaling pathway. 2019 Jan 3
32 30575440 Effect of melatonin on EGF- and VEGF-induced monolayer permeability of HUVECs. 2019 May 1 2
33 30648758 Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis. 2019 Apr 2
34 30809951 Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells. 2019 Sep 2
35 31024297 Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways. 2019 1
36 31025320 Melatonin attenuates TNF-α-mediated hepatocytes damage via inhibiting mitochondrial stress and activating the Akt-Sirt3 signaling pathway. 2019 Nov 4
37 31354524 Melatonin Enhances the Usefulness of Ionizing Radiation: Involving the Regulation of Different Steps of the Angiogenic Process. 2019 3
38 31386965 Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function. 2019 Sep 1
39 31619582 Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression. 2019 Oct 16 2
40 31836786 Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival. 2019 Dec 13 4
41 28655071 Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy. 2018 Jul 1 2
42 29196809 Melatonin affects membrane integrity, intracellular reactive oxygen species, caspase3 activity and AKT phosphorylation in frozen thawed human sperm. 2018 Apr 3
43 29247557 Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. 2018 Apr 2
44 29313427 Melatonin therapy for blunt trauma and strenuous exercise: A mechanism involving cytokines, NFκB, Akt, MAFBX and MURF-1. 2018 Aug 2
45 29322615 Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway. 2018 Nov 3
46 29330934 Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. 2018 Mar 1
47 29374563 Does the use of melatonin overcome drug resistance in cancer chemotherapy? 2018 Mar 1 1
48 29462594 Melatonin promotes neuroprotection of induced pluripotent stem cells-derived neural stem cells subjected to H2O2-induced injury in vitro. 2018 Apr 15 2
49 29484412 Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway. 2018 Apr 4
50 29607540 Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. 2018 Sep 1