Pub. Date : 2019 Nov
PMID : 31025320
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin attenuates TNF-alpha-mediated hepatocytes damage via inhibiting mitochondrial stress and activating the Akt-Sirt3 signaling pathway. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, we found that melatonin-regulated Sirt3 expression in a manner dependent on the Akt pathway. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Blockade of the Akt pathway abolished the protective exerted by melatonin on mitochondria and hepatocyte under TNF-alpha treatment. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | However, melatonin significantly increases the activity of the Akt/Sirt3 axis and consequently maintains mitochondrial homeostasis, restoring hepatocyte viability in an inflammatory environment. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |