Title : Melatonin Enhances the Usefulness of Ionizing Radiation: Involving the Regulation of Different Steps of the Angiogenic Process.

Pub. Date : 2019

PMID : 31354524






3 Functional Relationships(s)
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1 Melatonin also counteracted the stimulatory effect of radiation on CXCL6, CCL2, ERK1, ERK2, and AKT1 mRNA expression and increased the inhibitory effect of radiation on NOS3 expression. Melatonin AKT serine/threonine kinase 1 Homo sapiens
2 Melatonin potentiated the inhibitory effect on the activation of p-AKT and p-ERK exerted by radiation. Melatonin AKT serine/threonine kinase 1 Homo sapiens
3 Antiangiogenic effect of melatonin could be mediated through AKT and ERK pathways, proteins involved in vascular endothelial (VE) cell growth, cell proliferation, survival, migration, and angiogenesis. Melatonin AKT serine/threonine kinase 1 Homo sapiens