Pub. Date : 2020 Nov 20
PMID : 32758663
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin inhibits the apoptosis of rooster Leydig cells by suppressing oxidative stress via AKT-Nrf2 pathway activation. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, melatonin promoted the phosphorylation of AKT, while AKT inhibitor suppressed the Nrf2 pathway activated by melatonin and alleviated the inhibitory effects of melatonin on apoptosis and oxidative stress. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Furthermore, melatonin promoted the phosphorylation of AKT, while AKT inhibitor suppressed the Nrf2 pathway activated by melatonin and alleviated the inhibitory effects of melatonin on apoptosis and oxidative stress. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Furthermore, melatonin promoted the phosphorylation of AKT, while AKT inhibitor suppressed the Nrf2 pathway activated by melatonin and alleviated the inhibitory effects of melatonin on apoptosis and oxidative stress. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | In conclusion, melatonin could inhibit apoptosis in rooster Leydig cells by suppressing oxidative stress via activation of the AKT-Nrf2 pathway. | Melatonin | AKT serine/threonine kinase 1 | Homo sapiens |