Tyrosine

protein tyrosine kinase 2 ; Homo sapiens







675 Article(s)
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1 35125823 Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway. 2022 Jan 7 2
2 35257717 MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. 2022 May 5 3
3 35441172 Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist. 2022 Apr 11 1
4 35455022 Effects of Electrical Stimulation on the Signal Transduction-Related Proteins, c-Src and Focal Adhesion Kinase, in Fibroblasts. 2022 Apr 4 2
5 35467979 Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. 2022 Apr 26 2
6 35538070 EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation. 2022 May 10 2
7 33715263 ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain. 2021 Apr 1
8 33748278 Focal Adhesion Kinase Inhibitor Inhibits the Oxidative Damage Induced by Central Venous Catheter via Abolishing Focal Adhesion Kinase-Protein Kinase B Pathway Activation. 2021 1
9 33788628 TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells. 2021 Jun 1 2
10 33835469 Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells. 2021 Apr 20 2
11 31736196 Sensitization of HT29 colorectal cancer cells to vemurafenib in three-dimensional collagen cultures. 2020 Feb 1
12 31901221 A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade. 2020 Feb 1
13 31940873 FAK-Dependent Cell Motility and Cell Elongation. 2020 Jan 12 2
14 31969973 Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways. 2020 2
15 32007666 Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells. 2020 Mar 1 2
16 32044881 SERINE-910 Phosphorylated Focal Adhesion Kinase Expression Predicts Better Overall and Disease-free Survival in Melanoma. 2020 Feb 3
17 32148246 ADATMS-7 regulates the focal adhesion kinase signaling and promotes invasiveness of trophoblasts in early pregnancy. 2020 Mar 1
18 32510326 CD56 regulates human NK cell cytotoxicity through Pyk2. 2020 Jun 8 1
19 32594066 Glucose reduces the osmopressor response in connection with the tyrosine phosphorylation of focal adhesion kinase in red blood cells. 2020 May-Jun 1
20 32604782 Redox Regulation of NOX Isoforms on FAK(Y397)/SRC(Y416) Phosphorylation Driven Epithelial-to-Mesenchymal Transition in Malignant Cervical Epithelial Cells. 2020 Jun 26 1
21 32612176 A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. 2020 Jul 1 3
22 32655375 CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions. 2020 16
23 32760434 Bidirect effects from cisplatin combine with rosmarinic acid (RA) or hot water extracts of Glechoma hederacea (HWG) on renal cancer cells. 2020 1
24 33025708 FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. 2020 Nov 6 2
25 30773340 A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. 2019 Mar 18 1
26 30782981 Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697). 2019 Feb 19 1
27 31006845 Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration. 2019 Jun 2
28 31109284 High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site. 2019 May 20 1
29 31186741 ZINC4085554 inhibits cancer cell adhesion by interfering with the interaction of Akt1 and FAK. 2019 Jun 1
30 31285782 A Quantitative Method to Measure Low Levels of ROS in Nonphagocytic Cells by Using a Chemiluminescent Imaging System. 2019 4
31 31478830 FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. 2019 Sep 3 1
32 31565187 The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor. 2019 Sep 17 1
33 31671774 Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target. 2019 Oct 29 2
34 31905966 Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer. 2019 Dec 30 2
35 29022062 FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. 2018 Feb 2
36 29242050 Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLCγ1/Src-mediated paxillin hyperphosphorylation. 2018 Feb 2
37 29274473 Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. 2018 Feb 2
38 29292531 Focal adhesion kinases in head and neck squamous cell carcinoma. 2018 Mar 6
39 29322249 MiR-375 inhibits the hepatocyte growth factor-elicited migration of mesenchymal stem cells by downregulating Akt signaling. 2018 Apr 1
40 29535802 The KDEL receptor signalling cascade targets focal adhesion kinase on focal adhesions and invadopodia. 2018 Feb 13 1
41 29796177 Differential prognostic impact of interleukin-34 mRNA expression and infiltrating immune cell composition in intrinsic breast cancer subtypes. 2018 May 1 1
42 29928374 Cytotoxic activity of Shp2 inhibitor fumosorinone in human cancer cells. 2018 Jun 4
43 30364839 Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy. 2018 Oct 15 3
44 30488595 Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts. 2018 Nov 1
45 30488756 Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression. 2018 2
46 30498362 FAM129B promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients. 2018 1
47 31938172 Focal adhesion kinase (FAK) is associated with poor prognosis in urinary bladder carcinoma. 2018 2
48 27865925 Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation. 2017 Jun 1
49 27956712 Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells. 2017 May 1 2
50 27994061 Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. 2017 Feb 10 1