Pub. Date : 2020
PMID : 32655375
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CB1 Cannabinoid Receptors Stimulate Gbetagamma-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 2 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 3 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 4 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 5 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 6 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 7 | Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 8 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 9 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 10 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 11 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 12 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 13 | The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 14 | FAK 925 Tyr-P and ERK2 204 Tyr-P were blocked by the Gbetagamma inhibitor gallein, a GRK2 inhibitor, and GRK2 siRNA silencing, suggesting Gbetagamma and GRK2 participate in FAK-mediated ERK2 activation. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 15 | FAK 925 Tyr-P and ERK2 204 Tyr-P were blocked by the Gbetagamma inhibitor gallein, a GRK2 inhibitor, and GRK2 siRNA silencing, suggesting Gbetagamma and GRK2 participate in FAK-mediated ERK2 activation. | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |
| 16 | Together, these studies indicate FAK 925 Tyr-P occurs concurrently with CB1-stimulated ERK2 activation and requires the actin cytoskeleton and Gi/obetagamma-GRK2-mediated cross-talk between CB1, integrins, and receptor tyrosine kinases (RTKs). | Tyrosine | protein tyrosine kinase 2 | Homo sapiens |