Title : Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.

Pub. Date : 2017 Feb 10

PMID : 27994061






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanistically, we showed that FAK phosphorylates Beclin1, a core autophagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 association with Atg14L and reduces Beclin1-dependent autophagosome formation. Tyrosine protein tyrosine kinase 2 Homo sapiens