Title : EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation.

Pub. Date : 2022 May 10

PMID : 35538070






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Integrin beta1 activates focal adhesion kinase (FAK), which phosphorylates TGFbeta receptor type I (TGFbetaRI) at tyrosine 182 to enhance its binding to TGFbeta receptor type II (TGFbetaRII), thereby activating TGFbeta signaling. Tyrosine protein tyrosine kinase 2 Homo sapiens
2 Integrin beta1 activates focal adhesion kinase (FAK), which phosphorylates TGFbeta receptor type I (TGFbetaRI) at tyrosine 182 to enhance its binding to TGFbeta receptor type II (TGFbetaRII), thereby activating TGFbeta signaling. Tyrosine protein tyrosine kinase 2 Homo sapiens