| 1 |
34662393 | Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia. | 2022 Feb 10 |
3 |
| 2 |
34706199 | CD38-mediated Inhibition of Bruton's Tyrosine Kinase in Macrophages Prevents Endotoxemic Lung Injury. | 2022 Feb |
2 |
| 3 |
34897650 | Bruton's TK regulates myeloid cell recruitment during acute inflammation. | 2022 Jun |
1 |
| 4 |
35595730 | Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia. | 2022 May 20 |
1 |
| 5 |
32139435 | Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice. | 2021 Apr 1 |
4 |
| 6 |
32855532 | Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma. | 2021 May |
2 |
| 7 |
33168411 | Bruton's tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice. | 2021 Jan |
1 |
| 8 |
33561536 | Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice. | 2021 May |
2 |
| 9 |
33669187 | BTK Inhibition Reverses MDSC-Mediated Immunosuppression and Enhances Response to Anti-PDL1 Therapy in Neuroblastoma. | 2021 Feb 16 |
2 |
| 10 |
33746983 | Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy. | 2021 |
1 |
| 11 |
33831782 | NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice. | 2021 May 28 |
1 |
| 12 |
33851691 | Tirabrutinib hydrochloride for B-cell lymphomas. | 2021 Apr |
2 |
| 13 |
34031271 | Ibrutinib reduces neutrophil infiltration, preserves neural tissue and enhances locomotor recovery in mouse contusion model of spinal cord injury. | 2021 Sep 30 |
1 |
| 14 |
34112701 | Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells. | 2021 Jun 10 |
1 |
| 15 |
34605340 | Ibrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice. | 2021 Dec |
1 |
| 16 |
34726066 | Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis. | 2021 Nov 16 |
1 |
| 17 |
34895246 | Bruton's tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress. | 2021 Dec 11 |
2 |
| 18 |
31582534 | Ibrutinib Potentiates Antihepatocarcinogenic Efficacy of Sorafenib by Targeting EGFR in Tumor Cells and BTK in Immune Cells in the Stroma. | 2020 Feb |
3 |
| 19 |
31736210 | Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition. | 2020 Jan |
1 |
| 20 |
31895698 | Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis. | 2020 Apr 1 |
2 |
| 21 |
32025027 | Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells. | 2020 Mar |
2 |
| 22 |
32093809 | A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. | 2020 Sep 1 |
1 |
| 23 |
32272741 | Development of a Model for Chemical Screening Based on Collateral Sensitivity to Target BTK C481S Mutant. | 2020 Apr 7 |
2 |
| 24 |
32319217 | SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. | 2020 Sep |
1 |
| 25 |
32608058 | Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. | 2020 Oct |
2 |
| 26 |
32790160 | ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer. | 2020 Aug |
2 |
| 27 |
33092403 | Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase. | 2020 Dec 22 |
2 |
| 28 |
33162995 | X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure. | 2020 |
3 |
| 29 |
30646846 | Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia. | 2019 Jan 15 |
4 |
| 30 |
30819907 | p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape. | 2019 Oct |
1 |
| 31 |
31247078 | B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. | 2019 Jul 8 |
4 |
| 32 |
31364164 | A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies. | 2019 Dec |
1 |
| 33 |
31365830 | IL-6/p-BTK/p-ERK signaling mediates calcium phosphate-induced pruritus. | 2019 Nov |
2 |
| 34 |
31478435 | The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells. | 2019 Jan-Dec |
1 |
| 35 |
31505252 | Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy. | 2019 Oct |
2 |
| 36 |
31508518 | Pre-clinical anti-tumor activity of Bruton's Tyrosine Kinase inhibitor in Hodgkin's Lymphoma cellular and subcutaneous tumor model. | 2019 Aug |
1 |
| 37 |
31552054 | Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. | 2019 |
3 |
| 38 |
29398709 | Ibrutinib inhibition of ERBB4 reduces cell growth in a WNT5A-dependent manner. | 2018 Apr |
1 |
| 39 |
29483220 | p110α Inhibition Overcomes Stromal Cell-Mediated Ibrutinib Resistance in Mantle Cell Lymphoma. | 2018 May |
2 |
| 40 |
29516781 | Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. | 2018 Jul 1 |
1 |
| 41 |
29567142 | Molecular characterization and function analysis of grouper (Epinephelus coioides) Bruton's tyrosine kinase BTK. | 2018 Jun |
1 |
| 42 |
30013190 | Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma. | 2018 Nov |
1 |
| 43 |
30231870 | Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice. | 2018 Sep 19 |
2 |
| 44 |
30237801 | Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation. | 2018 |
1 |
| 45 |
30247919 | P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability. | 2018 Nov 5 |
6 |
| 46 |
30290988 | Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk. | 2018 Nov 15 |
1 |
| 47 |
30333099 | The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase. | 2018 Oct 23 |
1 |
| 48 |
28031181 | Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK. | 2017 Mar 2 |
3 |
| 49 |
28275136 | Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling. | 2017 Apr 15 |
1 |
| 50 |
28368423 | Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition. | 2017 Aug 10 |
1 |