Title : Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.

Pub. Date : 2020 Jan

PMID : 31736210






1 Functional Relationships(s)
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1 Here, we show that ibrutinib, a clinically approved covalent inhibitor of BTK, prolonged the maximum lifespan of a Zmpste24-/- progeroid mice, which also showed a reduction in general age-related fitness loss. ibrutinib Bruton agammaglobulinemia tyrosine kinase Mus musculus