Title : Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells.

Pub. Date : 2021 Jun 10

PMID : 34112701






1 Functional Relationships(s)
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1 The ITK/Bruton tyrosine kinase inhibitor ibrutinib has been shown to improve chronic GVHD symptoms; however, the effect of ITK selective inhibition on acute GVHD remains unclear. ibrutinib Bruton agammaglobulinemia tyrosine kinase Mus musculus