| 1 |
33140501 | dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells. | 2021 Jan |
1 |
| 2 |
33824328 | Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer. | 2021 Apr 6 |
2 |
| 3 |
30679536 | Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk. | 2019 Jan 24 |
1 |
| 4 |
30875637 | Deoxyuracil in DNA and disease: Genomic signal or managed situation? | 2019 May |
1 |
| 5 |
30902068 | Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis. | 2019 Mar 22 |
1 |
| 6 |
30987342 | CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. | 2019 Apr 4 |
1 |
| 7 |
31077566 | Evaluation of critical design parameters for RT-qPCR-based analysis of multiple dUTPase isoform genes in mice. | 2019 Jun |
1 |
| 8 |
29405473 | Inhibition of Dr-dut gene causes DNA damage in planarian. | 2018 Mar |
1 |
| 9 |
29435406 | The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase. | 2018 Feb |
1 |
| 10 |
29967751 | Single-nucleotide polymorphisms of uracil-processing genes affect the occurrence and the onset of recurrent depressive disorder. | 2018 |
1 |
| 11 |
28892519 | Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization. | 2017 Sep |
1 |
| 12 |
27063406 | Trading in cooperativity for specificity to maintain uracil-free DNA. | 2016 Apr 11 |
1 |
| 13 |
27325794 | The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine. | 2016 Sep 1 |
2 |
| 14 |
27933035 | Life without dUTPase. | 2016 |
3 |
| 15 |
25735890 | dUTPase expression correlates with cell division potential in Drosophila melanogaster. | 2015 May |
2 |
| 16 |
26666293 | Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. | 2015 Dec 15 |
1 |
| 17 |
22172489 | Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer. | 2012 Mar |
1 |
| 18 |
22339362 | Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. | 2012 Apr 12 |
1 |
| 19 |
22404301 | Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors. | 2012 Apr 12 |
4 |
| 20 |
22685418 | Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. | 2012 |
6 |
| 21 |
23085192 | Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei. | 2012 Dec 1 |
3 |
| 22 |
21541310 | Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis. | 2011 Apr 26 |
1 |
| 23 |
21548881 | Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme. | 2011 Jul 15 |
1 |
| 24 |
21576478 | HIV DNA is heavily uracilated, which protects it from autointegration. | 2011 May 31 |
1 |
| 25 |
21831832 | Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. | 2011 Aug 30 |
1 |
| 26 |
20227352 | The SOS screen in Arabidopsis: a search for functions involved in DNA metabolism. | 2010 May 4 |
1 |
| 27 |
20823546 | The structure of the genomic Bacillus subtilis dUTPase: novel features in the Phe-lid. | 2010 Sep |
1 |
| 28 |
18608754 | Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. | 2009 Feb |
1 |
| 29 |
18619713 | Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. | 2009 Feb |
1 |
| 30 |
18837522 | Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. | 2009 Jan 20 |
2 |
| 31 |
19015155 | Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. | 2009 Jan |
1 |
| 32 |
18586941 | Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation. | 2008 Sep |
1 |
| 33 |
18656547 | Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei. | 2008 |
1 |
| 34 |
18790783 | Novel opportunities for thymidylate metabolism as a therapeutic target. | 2008 Sep |
1 |
| 35 |
19055736 | Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. | 2008 Dec 2 |
1 |
| 36 |
17459559 | Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase. | 2007 Aug |
1 |
| 37 |
17544982 | Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives. | 2007 Jul |
1 |
| 38 |
16678429 | Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2. | 2006 Aug 15 |
1 |
| 39 |
16821778 | Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. | 2006 Jul 13 |
1 |
| 40 |
16964178 | Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. | 2006 Oct |
1 |
| 41 |
15884675 | Minimizing DNA contamination by using UNG-coupled quantitative real-time PCR on degraded DNA samples: application to ancient DNA studies. | 2005 Apr |
1 |
| 42 |
14724273 | Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer. | 2004 Apr 23 |
1 |
| 43 |
14724274 | Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme. | 2004 Apr 23 |
1 |
| 44 |
14996835 | Developmental regulation of dUTPase in Drosophila melanogaster. | 2004 May 21 |
1 |
| 45 |
15208312 | Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. | 2004 Oct 8 |
1 |
| 46 |
15322254 | Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. | 2004 Sep |
1 |
| 47 |
15571280 | Mechanistic studies of dUTPases. | 2004 Oct |
1 |
| 48 |
12670946 | A bifunctional dCTP deaminase-dUTP nucleotidohydrolase from the hyperthermophilic archaeon Methanocaldococcus jannaschii. | 2003 Jun 6 |
1 |
| 49 |
12721364 | Catalytic and structural role of the metal ion in dUTP pyrophosphatase. | 2003 May 13 |
1 |
| 50 |
12756253 | Structure of the bifunctional dCTP deaminase-dUTPase from Methanocaldococcus jannaschii and its relation to other homotrimeric dUTPases. | 2003 Jul 25 |
1 |