Title : Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

Pub. Date : 2009 Feb

PMID : 18619713






1 Functional Relationships(s)
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1 The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Uracil Deoxyuridine triphosphatase Drosophila melanogaster