Title : The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine.

Pub. Date : 2016 Sep 1

PMID : 27325794






2 Functional Relationships(s)
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1 Indeed, dUTPase or DCTPP1 down-regulation enhanced the cytotoxic effect of decitabine producing an accumulation of nucleoside triphosphates containing uracil as well as uracil misincorporation and double-strand breaks in genomic DNA. Uracil Deoxyuridine triphosphatase Drosophila melanogaster
2 Indeed, dUTPase or DCTPP1 down-regulation enhanced the cytotoxic effect of decitabine producing an accumulation of nucleoside triphosphates containing uracil as well as uracil misincorporation and double-strand breaks in genomic DNA. Uracil Deoxyuridine triphosphatase Drosophila melanogaster