Title : Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.

Pub. Date : 2004 Sep

PMID : 15322254






1 Functional Relationships(s)
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Protein Name
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1 dUTPase, which eliminates dUTP from the DNA biosynthetic pathway, opposes uracil misincorporation; therefore, elevation of this enzyme in cancer cells may contribute to drug resistance. Uracil Deoxyuridine triphosphatase Drosophila melanogaster