Pub. Date : 2012
PMID : 22685418
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 2 | We propose that the observed developmental pattern of uracil-DNA is due to the lack of the key repair enzyme UNG from the Drosophila genome together with down-regulation of dUTPase in larval tissues. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 3 | In agreement, we show that dUTPase silencing increases the uracil content in DNA of imaginal tissues and induces strong lethality at the early pupal stages, indicating that tolerance of highly uracil-substituted DNA is also stage-specific. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 4 | In agreement, we show that dUTPase silencing increases the uracil content in DNA of imaginal tissues and induces strong lethality at the early pupal stages, indicating that tolerance of highly uracil-substituted DNA is also stage-specific. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 5 | Silencing of dUTPase perturbs the physiological pattern of uracil-DNA accumulation in Drosophila and leads to a strongly lethal phenotype in early pupal stages. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 6 | These findings suggest a novel role of uracil-containing DNA in Drosophila development and metamorphosis and present a novel example for developmental effects of dUTPase silencing in multicellular eukaryotes. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |