Tyrosine

insulin like growth factor 1 ; Homo sapiens







197 Article(s)
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51 17264177 A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization. 2007 Apr 1
52 17346182 The IGF-I signaling pathway. 2007 1
53 17406898 A proteomic approach to the investigation of early events involved in the activation of vascular smooth muscle cells. 2007 Jul 2
54 17408801 Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation. 2007 Jun 1
55 17504916 Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis. 2007 Apr 1
56 17724138 Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner. 2007 Sep 1
57 17827393 Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway. 2007 Dec 15 2
58 17986823 Late effects of disturbed IGF signaling in congenital diseases. 2007 3
59 16195423 Occupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle. 2006 Jun 2
60 16239300 Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain. 2006 Feb 1
61 16619240 Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells. 2006 Aug 2
62 17046573 Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. 2006 Nov 2
63 15611085 RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. 2005 Mar 4 1
64 15705774 p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling. 2005 May 1
65 15870689 Interaction between Brk kinase and insulin receptor substrate-4. 2005 Aug 25 1
66 15888547 Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells. 2005 Jul 2
67 15998644 JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. 2005 Sep 9 1
68 16127155 Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. 2005 Sep 1
69 14593113 The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase. 2004 Jan 16 1
70 14697248 Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. 2004 Jan 16 3
71 15003536 IGF-I regulates caveolin 1 and IRS1 interaction in caveolae. 2004 Mar 26 3
72 15126563 Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells. 2004 May 1
73 15140184 Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival. 2004 May 1
74 15272055 Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. 2004 Nov 1
75 15291751 Requirement for G proteins in insulin-like growth factor-I-induced growth of prostate cells. 2004 Aug 1
76 15448167 The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt. 2004 Dec 10 1
77 15485651 IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. 2004 Nov 19 3
78 15501401 Nitric oxide decreases IGF-1 receptor function in vitro; glutathione depletion enhances this effect in vivo. 2004 Nov 1
79 15610023 Toward the insulin-IGF-I intermediate structures: functional and structural properties of the [TyrB25NMePheB26] insulin mutant. 2004 Dec 28 1
80 12556562 The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. 2003 Jan 1
81 12705864 Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. 2003 Apr 18 1
82 12730241 Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. 2003 Jul 11 1
83 12771153 Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. 2003 Aug 22 1
84 12960057 Growth factor-specific regulation of insulin receptor substrate-1 expression in MCF-7 breast carcinoma cells: effects on the insulin-like growth factor signaling pathway. 2003 Nov 1
85 12960075 Specificity of insulin-like growth factor I and insulin on Shc phosphorylation and Grb2 recruitment in caveolae. 2003 Dec 2
86 14559999 Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination. 2003 Nov 1
87 11786376 Dysregulation of IGF-I signaling in uterine leiomyoma. 2002 Jan 1
88 11834727 Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture. 2002 Apr 19 2
89 11861505 Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. 2002 Mar 1
90 12033942 Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. 2002 Jun 4 2
91 12058282 Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. 2002 Jul 1
92 12135605 IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. 2002 Aug 2 2
93 12149249 Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. 2002 Oct 11 1
94 12183434 Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor. 2002 Aug 15 1
95 11120746 Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth. 2001 Mar 9 1
96 11258708 A role for chemokine receptor transactivation in growth factor signaling. 2001 Feb 1
97 11316748 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. 2001 May 1
98 11376126 Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects. 2001 Jun 1
99 11416032 Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. 2001 Jul 1
100 11591350 Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation. 2001 Oct 1