Title : Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain.

Pub. Date : 2006 Feb

PMID : 16239300






1 Functional Relationships(s)
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1 Here, we show that IGF-II, but not IGF-I, induces potent autophosphorylation of residues Y1158, Y1162, and Y1163 in the activation loop of the kinase domain and tyrosine 960 in the juxtamembrane region of both IR-A and IR-B (exon 11+) isoforms. Tyrosine insulin like growth factor 1 Homo sapiens