Title : The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells.

Pub. Date : 2003 Jan

PMID : 12556562






1 Functional Relationships(s)
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1 Activation of the PI3K/AKT1 axis in resistant cells was dependent on enhanced tyrosine phosphorylation of the p85 regulatory subunit of PI3K, conceivably due to an autocrine insulin-like growth factor-I production. Tyrosine insulin like growth factor 1 Homo sapiens