Title : Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

Pub. Date : 2002 Jun 4

PMID : 12033942






2 Functional Relationships(s)
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Protein Name
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1 Dephosphorylation of basal Ser/Thr sites on F-IRS-1 also significantly reduced tyrosine phosphorylation by the IGF-1 receptor. Tyrosine insulin like growth factor 1 Homo sapiens
2 These data suggest that Ser/Thr phosphorylation can have both a positive and a negative regulatory role on tyrosine phosphorylation of IRS-1 and IRS-2 by insulin and IGF-1 receptors. Tyrosine insulin like growth factor 1 Homo sapiens