Title : Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue.

Pub. Date : 2001 Jul

PMID : 11416032






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Tyrosine insulin like growth factor 1 Homo sapiens