| 1 |
35410287 | Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs. | 2022 Apr 11 |
5 |
| 2 |
35429966 | Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways. | 2022 Apr 16 |
1 |
| 3 |
33303573 | Nutlin-3a Enhances Natural Killer Cell-Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors. | 2021 Feb |
1 |
| 4 |
33524216 | Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. | 2021 Feb |
1 |
| 5 |
33794285 | Effect of pharmacodynamical interaction between nutlin-3a and aspirin in the activation of p53. | 2021 Aug 7 |
2 |
| 6 |
34485982 | Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs. | 2021 |
1 |
| 7 |
31691131 | M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria. | 2020 Feb |
1 |
| 8 |
31767563 | Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers. | 2020 Jan 1 |
1 |
| 9 |
31774938 | Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination. | 2020 Feb 17 |
1 |
| 10 |
31866490 | CDK9 inhibitors reactivate p53 by downregulating iASPP. | 2020 Mar |
1 |
| 11 |
31918545 | Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice. | 2020 Feb 4 |
3 |
| 12 |
32063580 | Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill. | 2020 Apr |
2 |
| 13 |
32280825 | MDM2 Inhibition in a Subset of Sarcoma Cell Lines Increases Susceptibility to Radiation Therapy by Inducing Senescence in the Polyploid Cells. | 2020 Mar-Apr |
1 |
| 14 |
32611259 | Acylation of the antimicrobial peptide CAMEL for cancer gene therapy. | 2020 Dec |
1 |
| 15 |
32641480 | Reactivation of Epstein-Barr Virus by HIF-1α Requires p53. | 2020 Aug 31 |
1 |
| 16 |
32664789 | Significance of tumor protein p53 mutation in cellular process and drug selection in brain lower grade (WHO grades II and III) glioma. | 2020 Aug |
1 |
| 17 |
32800832 | F-box protein FBXO31 modulates apoptosis and epithelial-mesenchymal transition of cervical cancer via inactivation of the PI3K/AKT-mediated MDM2/p53 axis. | 2020 Oct 15 |
1 |
| 18 |
32874188 | The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276. | 2020 |
2 |
| 19 |
32934219 | CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells. | 2020 Sep 15 |
2 |
| 20 |
30389549 | The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway. | 2019 Jan |
1 |
| 21 |
30966857 | Comparison of genotoxic versus nongenotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks. | 2019 Apr |
2 |
| 22 |
31134974 | Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. | 2019 Jul 7 |
1 |
| 23 |
31502598 | Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. | 2019 Oct 21 |
1 |
| 24 |
31720601 | The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a. | 2019 Nov 26 |
3 |
| 25 |
29394130 | DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. | 2018 Jun 3 |
1 |
| 26 |
29803744 | SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation. | 2018 Oct 1 |
2 |
| 27 |
29842899 | The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein. | 2018 Aug 10 |
1 |
| 28 |
29980405 | Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. | 2018 Aug |
1 |
| 29 |
30096294 | PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a. | 2018 Oct 1 |
1 |
| 30 |
30355102 | Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. | 2018 Oct |
1 |
| 31 |
27177180 | Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist. | 2017 Feb |
1 |
| 32 |
27813088 | Nutlin-3a selects for cells harbouring TP53 mutations. | 2017 Feb 15 |
1 |
| 33 |
28416637 | A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. | 2017 Jul 1 |
1 |
| 34 |
28464864 | Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. | 2017 May 2 |
1 |
| 35 |
28798402 | Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis. | 2017 Aug 11 |
1 |
| 36 |
29141234 | Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells. | 2017 Nov 14 |
1 |
| 37 |
26556313 | Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. | 2016 Jan |
1 |
| 38 |
27547448 | Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. | 2016 |
1 |
| 39 |
27556362 | Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma. | 2016 Sep 20 |
2 |
| 40 |
27626308 | The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma. | 2016 Oct 25 |
1 |
| 41 |
25483068 | ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. | 2015 |
1 |
| 42 |
26158294 | p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3. | 2015 Jun 30 |
1 |
| 43 |
26431163 | Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors. | 2015 Oct 20 |
1 |
| 44 |
24268795 | Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents. | 2014 Jan 1 |
1 |
| 45 |
24366007 | Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. | 2014 Mar |
4 |
| 46 |
24473562 | Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells. | 2014 Jan |
2 |
| 47 |
24522962 | Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze). | 2014 Mar |
1 |
| 48 |
24867259 | Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. | 2014 Aug |
2 |
| 49 |
24921920 | Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. | 2014 Aug 12 |
1 |
| 50 |
24926617 | p53-directed translational control can shape and expand the universe of p53 target genes. | 2014 Oct |
1 |