Title : Human pregnane X receptor compromises the function of p53 and promotes malignant transformation.

Pub. Date : 2016

PMID : 27547448






1 Functional Relationships(s)
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Protein Name
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1 Consistent with the inhibitory effect of PXR on p53, elevated PXR levels decreased doxorubicin- or nutlin-3a-mediated toxicity and promoted malignant transformation in colon cancer cells. nutlin 3 tumor protein p53 Homo sapiens