Title : Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis.

Pub. Date : 2017 Aug 11

PMID : 28798402






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1 In this study, we show that treatment of various p53-defective bortezomib-resistant solid tumor cells with bortezomib plus nutlin-3 induces paraptosis, which is a cell death mode accompanied by dilation of the endoplasmic reticulum (ER) and mitochondria. nutlin 3 tumor protein p53 Homo sapiens