| 51 |
22469985 | Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. | 2013 Feb 28 |
3 |
| 52 |
23054209 | The non-genotoxic activator of the p53 pathway Nutlin-3 shifts the balance between E2F7 and E2F1 transcription factors in leukemic cells. | 2013 Apr |
1 |
| 53 |
23187459 | Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation. | 2013 Mar |
1 |
| 54 |
23398638 | Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2. | 2013 Apr 1 |
1 |
| 55 |
23720736 | MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. | 2013 Jul 19 |
1 |
| 56 |
23812671 | Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. | 2013 Aug 15 |
1 |
| 57 |
24127627 | Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale. | 2013 Nov 1 |
1 |
| 58 |
24154492 | Visualization and targeted disruption of protein interactions in living cells. | 2013 |
2 |
| 59 |
24231949 | p53-Based cyclotherapy: exploiting the 'guardian of the genome' to protect normal cells from cytotoxic therapy. | 2013 Dec 10 |
1 |
| 60 |
24270847 | On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein. | 2013 Dec 15 |
2 |
| 61 |
21725357 | MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. | 2012 Feb 9 |
1 |
| 62 |
22064349 | Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. | 2012 May |
3 |
| 63 |
22233735 | Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium. | 2012 Jan 10 |
1 |
| 64 |
22260869 | Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. | 2012 Mar 29 |
2 |
| 65 |
22785205 | Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. | 2012 Aug |
2 |
| 66 |
22830357 | The over-expression of miR-34a fails to block DoHH2 lymphoma cell proliferation by reducing p53 via c-MYC down-regulation. | 2012 Aug |
1 |
| 67 |
22948151 | Identification of HEXIM1 as a positive regulator of p53. | 2012 Oct 19 |
1 |
| 68 |
23187804 | p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3. | 2012 Dec 15 |
1 |
| 69 |
21068437 | Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. | 2011 Mar 3 |
1 |
| 70 |
21106726 | Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway. | 2011 Feb 15 |
1 |
| 71 |
21149449 | Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. | 2011 Feb 25 |
3 |
| 72 |
21173028 | MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response. | 2011 Jan |
1 |
| 73 |
21386967 | Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. | 2011 Feb 28 |
1 |
| 74 |
21460101 | Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3. | 2011 Jun |
1 |
| 75 |
21796156 | Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis. | 2011 Jul 28 |
2 |
| 76 |
22044530 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1. | 2011 Dec 19 |
1 |
| 77 |
22708054 | Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor. | 2011 Jan 1 |
2 |
| 78 |
19788889 | DNA damage response to the Mdm2 inhibitor nutlin-3. | 2010 Feb 15 |
1 |
| 79 |
20178585 | Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment. | 2010 Feb 23 |
1 |
| 80 |
20215548 | The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells. | 2010 Mar 15 |
1 |
| 81 |
20305378 | Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. | 2010 Apr 1 |
1 |
| 82 |
20422343 | Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation. | 2010 Aug |
1 |
| 83 |
20850924 | MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma. | 2010 Dec 28 |
1 |
| 84 |
21159614 | Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells. | 2010 Dec |
1 |
| 85 |
19188164 | MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma. | 2009 Feb 1 |
1 |
| 86 |
19190243 | Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism. | 2009 Apr 30 |
1 |
| 87 |
19421231 | Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells. | 2009 Sep |
3 |
| 88 |
19509161 | Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells. | 2009 Jun 15 |
1 |
| 89 |
19519319 | Exposure of B cell chronic lymphocytic leukemia (B-CLL) cells to nutlin-3 induces a characteristic gene expression profile, which correlates with nutlin-3-mediated cytotoxicity. | 2009 Jun |
1 |
| 90 |
19638586 | HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. | 2009 Aug 1 |
2 |
| 91 |
20157557 | Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3. | 2009 Sep 25 |
1 |
| 92 |
18092340 | Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. | 2008 May 15 |
1 |
| 93 |
18625847 | BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways. | 2008 Jul 14 |
1 |
| 94 |
18646312 | Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes. | 2008 Spring |
1 |
| 95 |
18677110 | Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. | 2008 Aug |
1 |
| 96 |
18779328 | Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. | 2008 Nov 7 |
1 |
| 97 |
18971636 | RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. | 2008 Nov 1 |
2 |
| 98 |
17138942 | Antiangiogenic activity of the MDM2 antagonist nutlin-3. | 2007 Jan 5 |
1 |
| 99 |
17146434 | Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. | 2007 May 24 |
1 |
| 100 |
17364023 | Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas. | 2007 Apr |
1 |