Pub. Date : 2014 Aug
PMID : 24867259
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report on how nutlin-3-stimulated ERK1/2 activity inhibits p53-induced apoptosis. | nutlin 3 | tumor protein p53 | Homo sapiens |
| 2 | Collectively, these results suggest that nutlin-3-activated ERK1/2 may stimulate the transcription of BCL2A1 via the activation of ELK1, and BCL2A1 expression may contribute to the inhibitory effect of ERK1/2 on nutlin-3-induced apoptosis, thereby constituting a negative feedback loop of p53-induced apoptosis. | nutlin 3 | tumor protein p53 | Homo sapiens |