Pub. Date : 2018 Mar
PMID : 29286156
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | In addition, metformin was able to activate p53, IFI16 and AMPK, in order to inhibit proliferation and migration of HASMCs. | Metformin | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, siRNA-mediated knockdown of p53 and IFI16 attenuated AMPK activation and reversed the suppressive effects of metformin. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | These results indicated that metformin-induced activation of AMPK suppresses the proliferation and migration of HASMCs by upregulating p53 and IFI16. | Metformin | tumor protein p53 | Homo sapiens |