Pub. Date : 2020 Sep 1
PMID : 32869837
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits the growth of ovarian cancer cells by promoting the Parkin-induced p53 ubiquitination. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | Further, up-regulated Parkin expression promoted the ubiquitination and degradation of p53, and metformin inhibited the expression of p53 to suppress the proliferation of chemo-resistant ovarian cancer cells. | Metformin | tumor protein p53 | Homo sapiens |
| 3 | Mechanistically, metformin could inhibit the growth of ovarian cancer cells by promoting the Parkin-induced p53 ubiquitination. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | Altogether, our study demonstrated an inhibitory role of metformin in the growth of chemo-resistant cancer cells through promoting the Parkin-induced p53 ubiquitination, which provides a novel mechanism of metformin for treating ovarian cancer. | Metformin | tumor protein p53 | Homo sapiens |
| 5 | Altogether, our study demonstrated an inhibitory role of metformin in the growth of chemo-resistant cancer cells through promoting the Parkin-induced p53 ubiquitination, which provides a novel mechanism of metformin for treating ovarian cancer. | Metformin | tumor protein p53 | Homo sapiens |