Pub. Date : 2019 Mar
PMID : 30936596
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic checkpoint and might inhibit cancer cell growth. | Metformin | tumor protein p53 | Homo sapiens |
2 | Real-time PCR revealed that metformin induced apoptosis in TE8 and TE11 cells by activating p53, down-regulating Bcl-2 expression. | Metformin | tumor protein p53 | Homo sapiens |
3 | Conclusion: Metformin induced apoptosis in ESCC by down-regulating Bcl-2 expression, and up-regulating p53 and induced apoptosis increased by 2-deoxy-d-glucose. | Metformin | tumor protein p53 | Homo sapiens |