benzyloxycarbonylleucyl-leucyl-leucine aldehyde

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







27 Article(s)
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1 34606682 DDX3 interacts with USP9X and participates in deubiquitination of the anti-apoptotic protein MCL1. 2022 Feb 2
2 32184020 Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. 2020 May 14 1
3 31117253 Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action. 2019 May 21 1
4 29074603 Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation. 2018 Jan 1 1
5 28301598 Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2. 2017 1
6 28419994 Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells. 2017 2
7 28939105 Protein kinase C-eta regulates Mcl-1 level via ERK1. 2017 Dec 1
8 27421828 Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. 2016 Oct 1
9 27875574 Chidamide Inhibits Aerobic Metabolism to Induce Pancreatic Cancer Cell Growth Arrest by Promoting Mcl-1 Degradation. 2016 1
10 24924397 Resveratrol and clofarabine induces a preferential apoptosis-activating effect on malignant mesothelioma cells by Mcl-1 down-regulation and caspase-3 activation. 2015 Mar 1
11 25344893 Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. 2015 Jan 1
12 26087957 MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine. 2015 Jul 1
13 21955141 The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells. 2013 Mar-Jun 1
14 23517112 TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages. 2013 Mar 22 1
15 23577147 Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. 2013 1
16 23703673 Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma. 2013 Oct 2
17 24261825 The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. 2013 Nov 22 1
18 22024133 Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. 2012 Jan 15 1
19 22314265 Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines. 2012 Jul 3
20 21170508 Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. 2011 Feb 2
21 21750559 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. 2011 Jul 12 1
22 22078414 Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors. 2011 Nov 14 1
23 18795123 Proteasome Inhibitor MG132 Induces Apoptosis and Inhibits Invasion of Human Malignant Pleural Mesothelioma Cells. 2008 Sep 1
24 17311906 Mcl-1 is downregulated in cisplatin-induced apoptosis, and proteasome inhibitors restore Mcl-1 and promote survival in renal tubular epithelial cells. 2007 Jun 2
25 16672643 The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism. 2006 Aug 1
26 12941295 Transcriptional and translational control of Mcl-1 during apoptosis. 2003 Sep 15 1
27 14562039 Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. 2003 Oct 16 1