Title : TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages.

Pub. Date : 2013 Mar 22

PMID : 23517112






1 Functional Relationships(s)
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1 RESULTS: Treatment with 0.5-1 muM MG132 alone or 30 ng/mL Bortezomib alone induced a limited apoptosis in MPM cells associated with the elevated Mcl-1 protein level and hyperactive PI3K/Akt signaling. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens