Title : Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.

Pub. Date : 2020 May 14

PMID : 32184020






1 Functional Relationships(s)
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1 PNT induced apoptosis (increased sub G1 cells, and cleaved caspase3 and PARP), and suppressed protein expression of MCL1, cyclin D2 and c-myc, which were reversed by a proteasome inhibitor, MG132, suggesting enhanced proteasomal degradation by PNT. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens