Title : Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation.

Pub. Date : 2018 Jan 1

PMID : 29074603






1 Functional Relationships(s)
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1 Decrease in Mcl-1 protein expression was abrogated by treatment with the proteasome inhibitor MG132, and was preceded by downregulation of the Mcl-1 deubiquitinase USP9X, a novel mechanism of Mcl-1 regulation in AML.Conclusions: The data support clinical testing of Pim and FLT3 inhibitor combination therapy for FLT3-ITD AML. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens