Title : Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines.

Pub. Date : 2012 Jul

PMID : 22314265






3 Functional Relationships(s)
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1 Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 The lack of an enhanced apoptosis induction could be correlated with high levels of Mcl-1 in response to the combined treatment with MG-132 and doxorubicin. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Thus, the results indicate that regulation of the antiapoptotic and proapoptotic Bcl-2 family members Noxa and Mcl-1 is predicative of the effectiveness of the combination of MG-132 with different anticancer agents on apoptosis induction in pancreatic cancer cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens