Title : Mcl-1 is downregulated in cisplatin-induced apoptosis, and proteasome inhibitors restore Mcl-1 and promote survival in renal tubular epithelial cells.

Pub. Date : 2007 Jun

PMID : 17311906






2 Functional Relationships(s)
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1 Preincubating cells with the proteasome inhibitor MG-132 or lactacystin not only restored cisplatin-induced loss of Mcl-1 but also resulted in an accumulation of Mcl-1 that exceeded basal levels; however, Bcl-2 and BclxL levels did not change in response to MG-132 or lactacystin. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Preincubating cells with the proteasome inhibitor MG-132 or lactacystin not only restored cisplatin-induced loss of Mcl-1 but also resulted in an accumulation of Mcl-1 that exceeded basal levels; however, Bcl-2 and BclxL levels did not change in response to MG-132 or lactacystin. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens