Title : MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.

Pub. Date : 2015 Jul

PMID : 26087957






1 Functional Relationships(s)
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1 Furthermore, the effect of MK-2206 on Mcl-1 downregulation was abolished by GSK3beta inhibitor, lithium chloride and proteasome inhibitor, MG-132, suggesting that MK-2206 acted through a GSK3beta-mediated, proteasome-dependent protein degradation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde MCL1 apoptosis regulator, BCL2 family member Homo sapiens