| 1 |
18000822 | MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome. | 2008 Mar 15 |
1 |
| 2 |
17695447 | A methionine-free diet associated with nitrosourea treatment down-regulates methylguanine-DNA methyl transferase activity in patients with metastatic cancer. | 2007 Jul-Aug |
2 |
| 3 |
14744281 | Correlation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea-based chemotherapy. | 2004 Feb |
2 |
| 4 |
12174880 | Adenoviral transfer of antisenses or ribozyme to O6-methylguanine-DNA methyltransferase mRNA in brain-tumor model resistant to chloroethyl-nitrosourea. | 2002 Jul-Aug |
1 |
| 5 |
10933201 | Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase. | 2000 May |
1 |
| 6 |
9927209 | Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone. | 1999 Jan 14 |
5 |
| 7 |
10352868 | Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients. | 1999 May |
8 |
| 8 |
10404096 | O(6)-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation. | 1999 Aug 20 |
2 |
| 9 |
10454526 | Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment. | 1999 Sep |
9 |
| 10 |
10565851 | Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo. | 1999 Dec |
2 |
| 11 |
9731508 | Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling. | 1998 Sep 1 |
2 |
| 12 |
17154443 | Clinical response of O(6)-methylguanine-DNA methyltransferase levels to 1,3-(2-chloroethyl)-1-nitrosourea chemotherapy in glioma patients. | 1998 Jun 15 |
7 |
| 13 |
8993023 | Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA. | 1997 Jan 15 |
1 |
| 14 |
9148943 | Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line. | 1997 May 16 |
4 |
| 15 |
9351972 | Evidence for nucleotide excision repair as a modifying factor of O6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines. | 1997 Nov |
2 |
| 16 |
9352585 | Understanding and manipulating O6-methylguanine-DNA methyltransferase expression. | 1997 |
3 |
| 17 |
9354444 | O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU. | 1997 Nov 1 |
1 |
| 18 |
9365163 | Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma. | 1997 |
1 |
| 19 |
8552605 | Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent. | 1996 Jan 9 |
2 |
| 20 |
8605218 | Quantification of O6-methylguanine-DNA methyltransferase mRNA in human brain tumors. | 1996 Feb 9 |
4 |
| 21 |
8616846 | Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene. | 1996 May 1 |
6 |
| 22 |
8632694 | Enhancement effect of O6-fluorobenzylguanines on chloroethylnitrosourea cytotoxicity in tumor cells. | 1996 |
6 |
| 23 |
8645346 | Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents. | 1996 May 3 |
1 |
| 24 |
8900378 | Human brain tumor O(6)-methylguanine-DNA methyltransferase mRNA and its significance as an indicator of selective chloroethylnitrosourea chemotherapy. | 1996 Oct 21 |
8 |
| 25 |
7554086 | The role of mRNA stability and transcription in O6-methylguanine DNA methyltransferase (MGMT) expression in Mer+ human tumor cells. | 1995 Sep |
6 |
| 26 |
7554090 | Transfer and expression of human O6-methylguanine-DNA methyltransferase cDNA confers resistance of Mer- HeLa MR cells to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a. | 1995 Sep |
2 |
| 27 |
7558444 | Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines. | 1995 Sep 27 |
7 |
| 28 |
8145054 | Characterization and chemosensitivity of two cell lines derived from human glioblastomas. | 1993 Aug |
1 |
| 29 |
8393842 | Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors. | 1993 Aug 19 |
1 |
| 30 |
1394230 | Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA. | 1992 Nov 1 |
2 |
| 31 |
1518162 | Expression of O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors. | 1992 Jun |
3 |
| 32 |
1531148 | Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. | 1992 Feb 19 |
3 |
| 33 |
1664221 | Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. | 1991 |
2 |
| 34 |
1825618 | Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro. | 1991 Mar 15 |
2 |
| 35 |
1893534 | Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines. | 1991 Sep |
1 |
| 36 |
3742731 | Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (MER+) to a sensitive tumor cell line (MER-) results in a tumor cell line resistant to MNNG and CNU that has increased O-6-methylguanine-DNA methyltransferase levels and reduced levels of DNA interstrand crosslinking. | 1986 Sep |
1 |
| 37 |
3948156 | Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base. | 1986 Apr |
2 |
| 38 |
3857628 | O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea. | 1985 May |
1 |
| 39 |
6585269 | Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts. | 1984 May |
1 |
| 40 |
6359062 | Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase. | 1983 Nov 25 |
2 |