Pub. Date : 1995 Sep 27
PMID : 7558444
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 2 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 3 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 4 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 5 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 6 | Activity of O6-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkylguanines in DNA by accepting the alkyl group at a cysteine moiety. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 7 | Potent MGMT inactivators (1-3, 5, 8, 9, 11) sensitize tumor cells to CENU chemotherapy. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Homo sapiens |