Title : Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.

Pub. Date : 1999 Dec

PMID : 10565851






2 Functional Relationships(s)
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1 We previously demonstrated that sustained depletion of methylguanine DNA methyltransferase (MGMT) activity is required for optimal reversal of chloroethylnitrosourea resistance in tumor cells. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Homo sapiens
2 We previously demonstrated that sustained depletion of methylguanine DNA methyltransferase (MGMT) activity is required for optimal reversal of chloroethylnitrosourea resistance in tumor cells. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Homo sapiens