Title : Understanding and manipulating O6-methylguanine-DNA methyltransferase expression.

Pub. Date : 1997

PMID : 9352585






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Homo sapiens
2 The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Homo sapiens
3 The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has made down-regulation of MGMT expression the key component in strategies designed to sensitize tumors to the cytotoxic potential of chloroethylnitrosoureas. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Homo sapiens