Dextromethorphan

cytochrome P450 family 2 subfamily D member 6 ; Homo sapiens







272 Article(s)
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51 25561870 Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin. 2014 Dec 2
52 23064959 Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer. 2013 Jan 2
53 23100173 CYP2D6 phenotype indicative for optimized antiestrogen efficacy associates with outcome in early breast cancer patients. 2013 Feb 2
54 23340533 Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain. 2013 Jan 3
55 23355638 A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women. 2013 Apr 1
56 23665933 CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. 2013 1
57 23835282 Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6. 2013 Sep 3
58 23881421 The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers. 2013 Nov 2
59 24013574 A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer. 2013 Oct 2
60 21842479 Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. 2012 Mar 1
61 21976621 Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. 2012 Jan 3
62 22039821 Pharmacophore, QSAR, and binding mode studies of substrates of human cytochrome P450 2D6 (CYP2D6) using molecular docking and virtual mutations and an application to chinese herbal medicine screening. 2012 Jul 1
63 22277677 Inter-individual variability of in vivo CYP2D6 activity in different genotypes. 2012 1
64 22305191 Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes. 2012 Mar 15 1
65 22422635 Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. 2012 Apr 1
66 22451032 Interleukin-6 and cytochrome-P450, reason for concern? 2012 Sep 1
67 22548589 Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice. 2012 Aug 4
68 22553469 The Discriminatory Value of CYP2D6 Genotyping in Predicting the Dextromethorphan/Dextrorphan Phenotype in Women with Breast Cancer. 2012 Feb 3
69 22762141 Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection. 2012 Aug 1
70 22777153 Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. 2012 Aug 2
71 21228393 Myoclonus after dextromethorphan administration in peritoneal dialysis. 2011 Jan 3
72 21365364 In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. 2011 Jul 1
73 21447389 Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. 2011 Jun 14 1
74 21456632 Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. 2011 May 1
75 21542294 [CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination]. 2011 Feb 2
76 21542297 [CYP2D6 genotypes and phenotypes in Chinese Han, Uygur and Kazakh populations]. 2011 Feb 1
77 21768449 Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment. 2011 Aug 20 2
78 21803659 Cytochrome P450 2D6 phenotyping in an elderly population with dementia and response to galantamine in dementia: a pilot study. 2011 Aug 2
79 21849623 Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys. 2011 Nov 2
80 22001938 Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization. 2011 Dec 1
81 24024018 Metabolic capacity of CYP2D6 within an Iranian population (Mazandaran Province). 2011 Spring 2
82 20041473 Effect of metabolic blockade on the psychoactive effects of dextromethorphan. 2010 Jan 4
83 20201775 Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. 2010 Jan 3
84 20473659 Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. 2010 Sep 3
85 20501912 Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan. 2010 Sep 3
86 20700584 Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population. 2010 Oct 3
87 20881950 Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. 2010 Nov 3
88 20940534 Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. 2010 Nov 2
89 21386204 Single time point diagnostic breath tests: a review. 2010 Mar 1
90 18543297 Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. 2009 Feb 4
91 18591960 The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction. 2009 Feb 1
92 18838503 Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes. 2009 Jan 4
93 19059219 The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol. 2009 Mar 1 2
94 19133059 Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment. 2009 Jan 2
95 19158312 Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese. 2009 Apr 7
96 19356111 O-demethylation of dextromethorphan using microbial cultures. 2009 Jan 2
97 19444798 A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. 2009 Nov 3
98 19817501 Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. 2009 1
99 17899220 Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study. 2008 Jan 1
100 17971818 The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. 2008 Feb 1