Title : Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer.

Pub. Date : 2013 Jan

PMID : 23064959






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1 PURPOSE: To assess the effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan HBr (CYP2D6 substrate) and theophylline (CYP1A2 substrate) in patients with metastatic castration-resistant prostate cancer (mCRPC). Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 CONCLUSION: Abiraterone acetate plus prednisone increased the exposure of dextromethorphan, suggesting a need for caution when coadministrating with known CYP2D6 substrates. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens