Pub. Date : 2010 Sep
PMID : 20501912
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolic assays of the CYP2D17 and CYP2D44 proteins heterologously expressed in Escherichia coli indicated that CYP2D44 metabolized human CYP2D6 substrates, bufuralol and dextromethorphan (bufuralol 1"-hydroxylation and dextromethorphan O-demethylation) but to a lesser extent than CYP2D17. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Metabolic assays of the CYP2D17 and CYP2D44 proteins heterologously expressed in Escherichia coli indicated that CYP2D44 metabolized human CYP2D6 substrates, bufuralol and dextromethorphan (bufuralol 1"-hydroxylation and dextromethorphan O-demethylation) but to a lesser extent than CYP2D17. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Kinetic analysis of dextromethorphan metabolism indicated that the apparent K(m) and V(max) of CYP2D17 and CYP2D44 catalyzed O-demethylation were similar, and, the V(max) values of CYP2D17 and CYP2D44 catalyzed N-demethylation (which human CYP2D6 catalyzes much less effectively) were similar, but the apparent K(m) of the CYP2D44 reaction was higher. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |