Pub. Date : 2010 Jan
PMID : 20201775
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To investigate the effects of black seed on the metabolic activities of CYP3A4 and CYP2D6 in human liver microsomes and in human subjects using dextromethorphan as a probe drug. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | CONCLUSION: Black seed significantly inhibited CYP2D6 and CYP3A4 mediated metabolism of DEX in human liver microsomes and healthy human volunteers indicating that it has the potential to interact with CYP2D6 and CYP3A4 substrates. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | CONCLUSION: Black seed significantly inhibited CYP2D6 and CYP3A4 mediated metabolism of DEX in human liver microsomes and healthy human volunteers indicating that it has the potential to interact with CYP2D6 and CYP3A4 substrates. | Dextromethorphan | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |