| 101 |
18056254 | CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528. | 2008 Mar |
2 |
| 102 |
18065299 | Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients. | 2008 Jan 1 |
2 |
| 103 |
18183034 | Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. | 2008 Jul |
1 |
| 104 |
18359183 | Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. | 2008 Jul |
2 |
| 105 |
18458004 | Metabolite profiling in human urine by LC-MS/MS: method optimization and application for glucuronides from dextromethorphan metabolism. | 2008 Aug 15 |
1 |
| 106 |
18692486 | Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. | 2008 Oct 1 |
1 |
| 107 |
18728242 | Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype. | 2008 Sep |
2 |
| 108 |
18794647 | The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans. | 2008 Oct |
2 |
| 109 |
18806696 | Clinical significance of a CYP2D6 poor metabolizer--a patient with schizophrenia on risperidone treatment. | 2008 Dec |
2 |
| 110 |
19051610 | Polymorphism of dextromethorphan oxidation in Polish population. | 2008 Sep-Oct |
1 |
| 111 |
17244768 | Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application. | 2007 Feb |
2 |
| 112 |
17273835 | Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. | 2007 Apr |
2 |
| 113 |
17371531 | Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. | 2007 Apr |
1 |
| 114 |
17392730 | Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. | 2007 Jun |
1 |
| 115 |
17409567 | Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153. | 2007 Apr |
1 |
| 116 |
17542019 | In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography. | 2007 Sep |
1 |
| 117 |
17719518 | Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6. | 2007 Jun |
1 |
| 118 |
17910620 | The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. | 2007 Nov |
1 |
| 119 |
18195464 | CYP2D6 phenotyping with dextromethorphan. | 2007 Nov-Dec |
3 |
| 120 |
16368922 | Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism. | 2006 Jan |
2 |
| 121 |
16414224 | Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. | 2006 May 24 |
1 |
| 122 |
16563352 | Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy. | 2006 May 12 |
6 |
| 123 |
16595712 | Expression, purification, and characterization of mouse CYP2d22. | 2006 Jul |
2 |
| 124 |
16913391 | Potential interactions of methylphenidate and atomoxetine with dextromethorphan. | 2006 Jul-Aug |
1 |
| 125 |
16984212 | Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers. | 2006 |
1 |
| 126 |
17050794 | Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women. | 2006 Nov |
1 |
| 127 |
17102541 | CYP2D6 genotype and phenotype relationship in South Indians. | 2006 Oct-Dec |
2 |
| 128 |
15792399 | Frequency distribution of dextromethorphan O-demethylation in a Greek population. | 2005 Mar |
1 |
| 129 |
15797796 | A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. | 2005 Apr 1 |
1 |
| 130 |
15821042 | Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance. | 2005 Jul |
2 |
| 131 |
15869321 | Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. | 2005 |
1 |
| 132 |
15988119 | Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers. | 2005 Jun |
2 |
| 133 |
16089243 | Dextromethorphan-induced delirium and possible methadone interaction. | 2005 Mar |
1 |
| 134 |
16176333 | Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. | 2005 Oct |
1 |
| 135 |
16222729 | Recombinant production of human microsomal cytochrome P450 2D6 in the methylotrophic yeast Pichia pastoris. | 2005 Nov |
2 |
| 136 |
16239355 | The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans. | 2005 Nov |
2 |
| 137 |
16269134 | Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6. | 2005 Dec 16 |
1 |
| 138 |
16283274 | Identification of CYP2D6 impaired functional alleles in Mexican Americans. | 2005 Dec |
2 |
| 139 |
16315033 | Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. | 2005 Dec |
9 |
| 140 |
16416672 | Phenotypical expression of CYP2D6 in amerindians of tepehuano origin from Durango, Mexico. | 2005 |
1 |
| 141 |
14992686 | Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite. | 2004 Jun 1 |
1 |
| 142 |
15018793 | Simple chromatography method for simultaneous determination of dextromethorphan and its main metabolites in human plasma with fluorimetric detection. | 2004 Apr 5 |
1 |
| 143 |
15025748 | Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. | 2004 Apr |
1 |
| 144 |
15060507 | Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate. | 2004 Apr |
1 |
| 145 |
15149890 | Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity. | 2004 Jun |
5 |
| 146 |
15252821 | Clomipramine, fluoxetine and CYP2D6 metabolic capacity in depressed patients. | 2004 Jul |
1 |
| 147 |
15556536 | LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation. | 2004 Dec 25 |
4 |
| 148 |
16680870 | The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6. | 2004 Apr |
1 |
| 149 |
12485954 | Differences in cytochrome P450 forms involved in the metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a novel sigma ligand, in human liver and intestine. | 2003 Jan |
1 |
| 150 |
12649767 | Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. | 2003 Jan |
1 |