| 1 |
34716917 | The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity. | 2022 Mar |
2 |
| 2 |
35014636 | The regioselectivity of the interaction between dextromethorphan and CYP2D6. | 2022 Jan 26 |
5 |
| 3 |
35257505 | Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups. | 2022 Apr |
3 |
| 4 |
33060488 | Plasma Concentrations and Cardiovascular Effects of Citalopram Enantiomers After Oral Versus Infusion Citalopram Therapy in Dextromethorphan-Mephenytoin-Phenotyped Patients With Major Depression. | 2021 Jun 1 |
1 |
| 5 |
33376147 | Tryptophan-75 Is a Low-Energy Channel-Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6. | 2021 Mar |
1 |
| 6 |
33434947 | Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. | 2021 Mar |
3 |
| 7 |
33792897 | Exploring the Use of Serum-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Hepatic Cytochromes P450 and Organic Anion Transporting Polypeptides. | 2021 Jul |
3 |
| 8 |
33831979 | In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6. | 2021 Apr 8 |
1 |
| 9 |
34352333 | OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations. | 2021 Oct 10 |
1 |
| 10 |
34355409 | Effects of age and gender on the cytochrome P450 2D6 activity in a Korean population. | 2021 Dec |
3 |
| 11 |
34569808 | Substrate specificity of CYP2D6 genetic variants. | 2021 Nov |
1 |
| 12 |
34821124 | In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6. | 2021 Apr 9 |
1 |
| 13 |
31814297 | The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients. | 2020 May |
1 |
| 14 |
32037159 | CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity. | 2020 Feb |
2 |
| 15 |
32691726 | Profile of the inhibitory effects of gefitinib on CYP2D6 variants in vitro. | 2020 Oct |
4 |
| 16 |
32813313 | Predicting steady-state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable? | 2020 Oct |
2 |
| 17 |
29874682 | Psychiatric Disorder or Adverse Drug Reaction? - How CYP2D6 Metabolizing Activity Can Result in Dextromethorphan Intoxication. | 2019 Jan |
1 |
| 18 |
30192434 | Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes. | 2019 Feb |
1 |
| 19 |
30842914 | Evaluation of dextromethorphan with select antidepressant therapy for the treatment of depression in the acute care psychiatric setting. | 2019 Mar |
1 |
| 20 |
31239454 | Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective. | 2019 Jun 25 |
1 |
| 21 |
31268632 | Physiologically-Based Pharmacokinetic Modeling for the Prediction of CYP2D6-Mediated Gene-Drug-Drug Interactions. | 2019 Aug |
1 |
| 22 |
31637538 | Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib. | 2019 Oct 21 |
1 |
| 23 |
29719052 | Effect of single-walled carbon nanotubes on cytochrome P450 activity in human liver microsomes in vitro. | 2018 May |
1 |
| 24 |
29784728 | CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. | 2018 Aug |
1 |
| 25 |
29882961 | CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction. | 2018 Nov |
1 |
| 26 |
30219715 | Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants. | 2018 Oct |
2 |
| 27 |
27317395 | Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound. | 2017 Jun |
1 |
| 28 |
28211700 | From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans. | 2017 Mar 6 |
1 |
| 29 |
28271978 | Lessons from Cuba for Global Precision Medicine: CYP2D6 Genotype Is Not a Robust Predictor of CYP2D6 Ultrarapid Metabolism. | 2017 Jan |
1 |
| 30 |
28290770 | In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report. | 2017 Apr |
2 |
| 31 |
28449367 | Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease. | 2017 Oct |
1 |
| 32 |
28786716 | Evaluation of CYP2D6 phenotype in the Yoruba Nigerian population. | 2017 Oct |
2 |
| 33 |
32095466 | Prediction and visualization of CYP2D6 genotype-based phenotype using clustering algorithms. | 2017 Sep |
2 |
| 34 |
26310775 | Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. | 2016 Mar |
2 |
| 35 |
26452722 | Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes. | 2016 Jan |
1 |
| 36 |
27023460 | Effects of the Chinese herbal formula "Zuojin Pill" on the pharmacokinetics of dextromethorphan in healthy Chinese volunteers with CYP2D6*10 genotype. | 2016 Jun |
2 |
| 37 |
25324279 | Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone. | 2015 Feb |
1 |
| 38 |
25619394 | Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells. | 2015 Feb |
2 |
| 39 |
25682269 | CYP2D44 polymorphisms in cynomolgus and rhesus macaques. | 2015 Jul |
1 |
| 40 |
25891764 | Further characterization of a ¹³C-dextromethorphan breath test for CYP2D6 phenotyping in breast cancer patients on tamoxifen therapy. | 2015 Apr 20 |
1 |
| 41 |
26195224 | Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6. | 2015 Aug |
1 |
| 42 |
26597400 | CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study. | 2015 Dec |
2 |
| 43 |
23985325 | Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity. | 2014 Jan 1 |
1 |
| 44 |
24167220 | Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes. | 2014 Jan |
1 |
| 45 |
24682508 | Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy. | 2014 Jun |
1 |
| 46 |
24697814 | Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen. | 2014 Sep |
2 |
| 47 |
24711855 | Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4. | 2014 |
1 |
| 48 |
24747158 | Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients. | 2014 Aug |
1 |
| 49 |
24985704 | Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism. | 2014 Sep |
2 |
| 50 |
24987171 | Evaluation of cytochrome P450 2D6 phenotyping in healthy adult Western Indians. | 2014 May-Jun |
1 |