Title : Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes.

Pub. Date : 2014 Jan

PMID : 24167220






1 Functional Relationships(s)
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1 Sarpogrelate potently and selectively inhibited CYP2D6-mediated dextromethorphan O-demethylation with an IC50 (Ki) value of 3.05 muM (1.24 muM), in a competitive manner. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens