Title : Exploring the Use of Serum-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Hepatic Cytochromes P450 and Organic Anion Transporting Polypeptides.

Pub. Date : 2021 Jul

PMID : 33792897






3 Functional Relationships(s)
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1 It was also possible to measure liver sEV-catalysed dextromethorphan (DEX) O-demethylation to dextrorphan (DXO), correlated with sEV CYP2D6 expression (r = 0.917, P = 0.0001; N = 10) and 3hr plasma DXO-to-DEX concentration ratio (r = 0.843, P = 0.002; N = 10), and show that CYP2D6 was not induced by RIF. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 It was also possible to measure liver sEV-catalysed dextromethorphan (DEX) O-demethylation to dextrorphan (DXO), correlated with sEV CYP2D6 expression (r = 0.917, P = 0.0001; N = 10) and 3hr plasma DXO-to-DEX concentration ratio (r = 0.843, P = 0.002; N = 10), and show that CYP2D6 was not induced by RIF. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens
3 It was also possible to measure liver sEV-catalysed dextromethorphan (DEX) O-demethylation to dextrorphan (DXO), correlated with sEV CYP2D6 expression (r = 0.917, P = 0.0001; N = 10) and 3hr plasma DXO-to-DEX concentration ratio (r = 0.843, P = 0.002; N = 10), and show that CYP2D6 was not induced by RIF. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens